CNS Disease Modeling Group

About CNS Disease Modeling Group

Our lab has as a main interest the neurodegenerative process in Parkinson’s disease and other alpha-synucleinopathies. Our main tools of work are animal models of the disease: from neurotoxin based models to transgenic models, both classic transgenic mice lines and adult transgenesis models by means of viral vectors. The team has focused during the last years in those possible events initiated as a consequence of the overexpression and or mishandling of the protein alpha-synuclein that contribute to the disease process. In addition we have an interest on the processes occurring in the immune system during the neurodegenerative event and how both, local and peripheral immune cells, can modify the neuronal survival. Our fundamental goal is to reveal new targets for disease modification that can be ultimately used to develop novel therapies for the patients.

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Research Focus

  • Alpha-synuclein
  • Early vs. late Parkinson’s disease
  • Dopaminergic vs. non dopaminergic neurodegeneration
  • Microglia
  • Neuroinflammation
  • Neuroprotection

Techniques / Infrastructure

  • Stereotactic Brain Surgery
  • Immunomodulation, vaccination, and cell transplantation
  • Motor-behavioural analyses of rodents
  • Histological analysis of brains
  • Sterological quantification of brain cells
  • Biochemical analysis of brain proteins
  • Cytometric analysis of cells


Marina Romero-Ramos, Ph.D.
Associate Professor
Dept. of Biomedicine
Høegh-Guldbergs Gade 10, bldg. 1115, room 120
Aarhus University
DK-8000C Aarhus, Denmark

Office : +45 60202749



Gitte Ulbjerg Toft
Laboratory Technician
Dept. of Biomedicine
Høegh-Guldbergs Gade 10, bldg. 1115, room 125
Aarhus University
DK-8000C Aarhus, Denmark

Lab: +45 87167048

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