Protein Biophysics Group

About Protein Biophysics Group

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level. 

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Research Focus

Techniques/Infrastructure

Contact

Daniel Erik Otzen
Professor, Ph.D.
Aarhus University
Interdisciplinary Nanoscience Centre
Department of Molecular Biology
Gustav Wieds Vej 10 C
8000 Aarhus C
DENMARK

Tel.: +45 2072 5238
Fax: +45 8612 3178
Email:dao@inano.au.dk

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