The main focus of our research is the molecular neurophysiology of the hippocampus in rodents. Hippocampus is a key structure of the brain involved in learning and memory which in a mouse model is especially suited for laboratory analyses of the molecular mechanisms underlying brain processes. A thorough characterization of the functional properties of the synapses in the brain is fundamental for our understanding of the healthy as well as the diseased brain. We take advantage of transgenic animal models and combine these with pharmacological tools. We prepare thin brain sections for electrophysiological studies such as extracellular field recordings or patch clamp techniques. The functional analyses are combined with structural studies using immunohistochemistry. Key projects in the lab focus on the sortilin related receptor SORCS3, a mouse model of ALS and allosteric modulators of AMPA receptors. Ultimately our studies may help future patients suffering from brain-related disorders.