Laboratory of Molecular Neurophysiology and Plasticity

About Laboratory of Molecular Neurophysiology and Plasticity

The main focus of our research is the molecular neurophysiology of the hippocampus in rodents. Hippocampus is a key structure of the brain involved in learning and memory which in a mouse model is especially suited for laboratory analyses of the molecular mechanisms underlying brain processes. A thorough characterization of the functional properties of the synapses in the brain is fundamental for our understanding of the healthy as well as the diseased brain. We take advantage of transgenic animal models and combine these with pharmacological tools. We prepare thin brain sections for electrophysiological studies such as extracellular field recordings or patch clamp techniques. The functional analyses are combined with structural studies using immunohistochemistry. Key projects in the lab focus on the sortilin related receptor SORCS3, a mouse model of ALS and allosteric modulators of AMPA receptors. Ultimately our studies may help future patients suffering from brain-related disorders. 

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Research Focus

  • Molecular mechanisms underlying synaptic plasticity
  • The postsynaptic sortilin receptor SORCS3
  • Positive allosteric modulators of AMPA receptors
  • The wobbler mouse model of ALS
  • Rodent models of brain diseases

Techniques/Infrastructure

  • Extracellular field recordings (studies of basal synaptic transmission and vesicle release properties)
  • Studies of synaptic plasticity (long-term depression (LTD) and long-term potentiation (LTP))
  • Patch-clamp studies of inhibitory and excitatory neurotransmission in brain slices
  • Mechanistic studies of selected pharmacological tools targeting neuronal receptors and channels
  • Immunohistochemical staining of selected markers in brain sections
  • PCR-based genotyping of transgenic mice

Contact

Mai Marie Holm
Associate Professor, PhD
Department of Biomedicine
Aarhus University
Ole Worms Allé, Bldg 1160, room 122
DK-8000 Aarhus C
Denmark

E-mail: mmh@biomed.au.dk
Web: www.biomed.au.dk/mmh
Tel: +45 8716 7715

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